Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc14.2 | Male Reproduction | ICEECE2012

Deficient expression of genes involved in the endogenous defense system against transposons in cryptorchid boys with impaired mini-puberty

Hadziselimovic F. , Hadziselimovic N. , Demougin P. , Oakeley E.

Mini-puberty is the period between 30 and 80 days after birth when testosterone and gonadotropin surges occur in male infants to induce the transformation of gonocytes into Ad (adult/dark) spermatogonia. Cryptorchid boys with impaired mini-puberty develop infertility despite timely and successful surgical treatment. The decreased germ cell count found in this group of boys could be the result of uncontrolled transposon activity inducing genomic instability and germ cell death....